European Journal of Chemistry

Synthesis, characterization and crystal structure of ethyl 4-(3-chloro benzamido)benzoate



Main Article Content

Aamer Saeed
Hummera Rafique
Ulrich Flörke

Abstract

The title compound was efficiently synthesized in two steps starting from esterification of 4-aminobenzoic acid followed by amidation with 3-chlorobenzoyl chloride in dry tetrahydrofuran. The structure was confirmed by spectroscopic data and elemental analysis. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1 with Z = 2 and unit cell dimensions a = 5.2941(15) Å, b = 8.157(2) Å, c = 16.238(4) Å, α = 82.682(6)°, β = 84.481(6)°, γ = 80.100(6)° and V = 683.2(3) Å3.

1_4_289_290_800


icon graph This Abstract was viewed 1475 times | icon graph Article PDF downloaded 794 times icon graph Article CIF FILE downloaded 0 times

How to Cite
(1)
Saeed, A.; Rafique, H.; Flörke, U. Synthesis, Characterization and Crystal Structure of Ethyl 4-(3-Chloro benzamido)benzoate. Eur. J. Chem. 2010, 1, 289-290.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Omar, F. A.; Mahfouz, N. M.; Rahman, M. A. Eur. J. Med. Chem. 1996, 31, 819-825.
doi:10.1016/0223-5234(96)83976-6

[2]. Amir, M.; Oberoi, A.; Alam, S. Indian J. Chem. 1999, 38B, 237-242.

[3]. Palaska, E.; Sahin, G.; Kelicen, P.; Durlu, N. T.; Altinok, G. Farmaco 2002, 57, 101-107.
doi:10.1016/S0014-827X(01)01176-4

[4]. Kumar, A.; Bansal, D.; Bajaj, K.; Sharma, S.; Archana, K.; Srivastava, V. K. Bioorg. Med. Chem. 2003, 11, 5281-5291.
doi:10.1016/S0968-0896(03)00529-7

[5]. Jackson, S.; DeGrado, W.; Dwivedi, A.; Parthasarathy, A.; Higley, A.; Krywko, J.; Rockwell, A.; Markwalder, J.; Wells, G.; Wexler, R.; Mousa, S.; Harlow, R. J. Am. Chem. Soc. 1994, 116, 3220-3230.
doi:10.1021/ja00087a007

[6]. Capdeville, R.; Buchdunger, E.; Zimmermann, J.; Matter, J. Nat. Rev. Drug Discovery. 2002, 1, 493-502.
doi:10.1038/nrd839
PMid:12120256

[7]. Manley, P. W.; Furet, P.; Bold, G.; Bruggen, J.; Mestan, J.; Meyer, T.; Schnell, C. R.; Wood, J. J. Med. Chem. 2002, 45, 5687-5693.
doi:10.1021/jm020899q
PMid:12477352

Supporting Agencies

TrendMD

Dimensions - Altmetric - scite_ - PlumX
publications
2
supporting
0
mentioning
0
contrasting
0
Smart Citations
2
0
0
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Downloads and views

Downloads

Metrics

PDF views
794
Jan 2011Jul 2011Jan 2012Jul 2012Jan 2013Jul 2013Jan 2014Jul 2014Jan 2015Jul 2015Jan 2016Jul 2016Jan 2017Jul 2017Jan 2018Jul 2018Jan 2019Jul 2019Jan 2020Jul 2020Jan 2021Jul 2021Jan 2022Jul 2022Jan 2023Jul 2023Jan 2024Jul 2024Jan 2025Jul 2025Jan 202623
|
DataCite
1
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).